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| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Common Stock Value | 1.29 | 1.29 | 1.28 | 1.26 | 1.26 | 1.25 | 1.25 | 1.24 | 1.24 | 1.23 | 1.21 | 1.21 | 1.20 | 1.20 | 1.19 | 1.17 | 1.16 | 1.16 | 1.16 | 1.13 | 1.12 | 1.11 | 1.11 | 1.06 | 1.01 | 1.01 | 1.00 | 1.00 | NA | 1.00 | 0.92 | 0.92 | 0.86 | |
| Weighted Average Number Of Diluted Shares Outstanding | NA | 128.59 | 126.73 | 126.14 | NA | 131.34 | 124.66 | 124.11 | NA | 122.17 | 120.90 | 120.39 | NA | 119.14 | 117.77 | 117.08 | NA | 115.99 | 114.91 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Weighted Average Number Of Shares Outstanding Basic | NA | 128.59 | 126.73 | 126.14 | NA | 125.22 | 124.66 | 124.11 | NA | 122.17 | 120.90 | 120.39 | NA | 119.14 | 117.77 | 117.08 | NA | 115.99 | 114.91 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Earnings Per Share Basic | -0.65 | -0.87 | -0.13 | -0.52 | -1.09 | 1.18 | -2.21 | -1.40 | -1.68 | -3.32 | -2.29 | -2.00 | -2.16 | -1.72 | -1.61 | -1.71 | -2.09 | -2.18 | -1.56 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Earnings Per Share Diluted | -0.65 | -0.87 | -0.13 | -0.52 | -1.09 | 1.15 | -2.21 | -1.40 | -1.68 | -3.32 | -2.29 | -2.00 | -2.16 | -1.72 | -1.61 | -1.71 | -2.09 | -2.18 | -1.56 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue From Contract With Customer Excluding Assessed Tax | 593.17 | 500.92 | 659.83 | 494.33 | 439.72 | 750.53 | 318.75 | 319.29 | 335.04 | 264.31 | 224.82 | 213.26 | 258.54 | 187.63 | 220.55 | 177.57 | 163.56 | 125.85 | 103.96 | 99.48 | 71.68 | 70.06 | 44.71 | 33.29 | 21.03 | 2.07 | 29.91 | 21.90 | 2.90 | 37.92 | 17.10 | 15.93 | 18.96 | |
| Revenues | 593.17 | 500.92 | 659.83 | 494.33 | 439.72 | 750.53 | 318.75 | 319.29 | 335.04 | 264.31 | 224.82 | 213.26 | 258.54 | 187.63 | 220.55 | 177.57 | 163.56 | 125.85 | 103.96 | 99.48 | 71.68 | 70.06 | 44.71 | 33.29 | 21.03 | 2.07 | 29.91 | 21.90 | 2.90 | 37.92 | 17.10 | 15.93 | 18.96 | |
| Cost Of Goods And Services Sold | 102.65 | 81.98 | 67.27 | 54.61 | 71.97 | 79.47 | 75.34 | 41.43 | 46.17 | 36.51 | 34.04 | 23.46 | 33.63 | 28.09 | 30.26 | 23.02 | 23.02 | 21.80 | 19.93 | 13.30 | 12.18 | 5.21 | 4.33 | 3.35 | 1.67 | 0.14 | NA | NA | NA | NA | NA | NA | NA | |
| Costs And Expenses | 698.33 | 577.82 | 611.21 | 537.77 | 556.12 | 536.66 | 548.59 | 469.10 | 523.65 | 522.35 | 416.50 | 359.99 | 453.10 | 369.31 | 366.71 | 363.82 | 357.78 | 351.05 | 302.82 | 309.63 | 369.75 | 286.36 | 280.99 | 222.08 | 241.39 | 256.63 | 222.26 | 169.30 | NA | 185.23 | 142.90 | 136.41 | 125.47 | |
| Research And Development Expense | 300.17 | 270.93 | 294.14 | 261.00 | 272.14 | 253.18 | 248.53 | 230.57 | 262.04 | 245.37 | 205.71 | 169.89 | 229.05 | 194.57 | 182.63 | 185.90 | 168.47 | 161.78 | 155.00 | 169.57 | 201.30 | 160.80 | 163.89 | 129.13 | 131.04 | 139.94 | 137.58 | 96.86 | NA | 117.77 | 95.25 | 90.63 | 86.98 | |
| Selling General And Administrative Expense | 295.34 | 220.99 | 248.40 | 210.80 | 198.12 | 199.18 | 214.69 | 183.66 | 210.34 | 235.86 | 169.98 | 154.47 | 186.38 | 142.07 | 145.32 | 146.86 | 166.29 | 167.47 | 127.90 | 126.76 | 156.28 | 120.35 | 112.77 | 89.61 | 108.69 | 116.55 | 84.68 | 72.45 | NA | 67.45 | 47.64 | NA | NA | |
| Operating Income Loss | -105.16 | -76.91 | 48.61 | -43.44 | -116.40 | 213.87 | -229.83 | -149.81 | -188.61 | -258.04 | -191.69 | -146.73 | -194.56 | -181.68 | -146.16 | -186.25 | -194.22 | -225.20 | -198.86 | -210.16 | -298.07 | -216.30 | -236.27 | -188.79 | -220.36 | -254.56 | -192.35 | -147.41 | NA | -147.30 | -125.80 | -120.47 | -106.51 | |
| Interest Paid Net | 12.33 | 16.15 | 8.16 | 30.95 | 5.44 | 9.55 | 3.22 | 13.91 | 1.30 | 14.87 | 14.94 | 14.12 | 6.95 | 9.35 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Allocated Share Based Compensation Expense | 91.64 | 45.80 | 89.29 | 45.35 | 41.99 | 63.94 | 75.80 | 39.95 | 42.77 | 128.12 | 30.47 | 29.29 | 44.58 | 33.37 | 32.08 | 55.69 | 34.28 | 37.26 | 33.76 | 34.58 | 66.20 | 46.01 | 30.60 | 32.03 | 27.97 | 87.95 | 22.24 | 19.58 | NA | NA | NA | NA | NA | |
| Income Tax Expense Benefit | -110.19 | 2.91 | 5.72 | 2.35 | 0.18 | 2.99 | 1.81 | 1.74 | 0.47 | -0.02 | 2.73 | 0.98 | -1.84 | 0.28 | 1.23 | 1.02 | -0.06 | 0.84 | 1.33 | 0.57 | -0.40 | -0.39 | 0.96 | 0.69 | 0.36 | 0.45 | 0.08 | -0.06 | NA | NA | NA | NA | NA | |
| Other Comprehensive Income Loss Net Of Tax | -9.69 | 9.81 | -7.65 | -3.61 | 8.96 | 4.74 | 2.04 | 5.53 | -0.87 | -1.56 | -4.16 | -4.81 | 0.97 | 1.85 | 0.64 | 6.91 | -6.43 | -3.98 | -1.15 | 4.46 | -2.15 | 1.46 | -2.98 | 0.36 | 0.18 | 0.41 | 1.05 | -0.42 | NA | NA | NA | NA | NA | |
| Net Income Loss | -83.76 | -111.57 | -16.89 | -65.94 | -137.87 | 147.75 | -276.02 | -174.10 | -207.49 | -405.92 | -277.40 | -240.34 | -258.46 | -204.51 | -189.56 | -200.29 | -243.54 | -253.29 | -179.23 | -182.22 | -276.19 | -208.53 | -219.48 | -181.91 | -211.44 | -245.28 | -163.56 | -141.21 | NA | -142.23 | -122.94 | -118.42 | -107.29 | |
| Comprehensive Income Net Of Tax | -93.45 | -101.76 | -24.54 | -69.55 | -128.91 | 152.49 | -273.98 | -168.57 | -208.36 | -407.48 | -281.56 | -245.15 | -257.49 | -202.66 | -188.92 | -193.39 | -249.97 | -257.27 | -180.38 | -177.76 | -278.33 | -207.07 | -222.46 | -181.56 | -211.26 | -244.87 | -162.51 | -141.63 | NA | -142.92 | -122.72 | -118.55 | -107.68 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Assets | 4239.98 | 4205.04 | 4009.63 | 3824.39 | 3829.88 | 3839.07 | 3402.40 | 3391.94 | 3546.36 | 3535.26 | 3330.42 | 3433.55 | 3643.30 | 3472.31 | 3509.43 | 3255.27 | 3407.06 | 3307.28 | 3374.37 | 2279.62 | 2395.13 | 2541.62 | 2716.41 | 2014.00 | 1574.80 | 1675.65 | 1789.39 | 1923.14 | NA | 1994.73 | 1358.28 | 1434.28 | 1133.93 | |
| Liabilities | 4172.90 | 4172.69 | 4012.70 | 4043.66 | 4050.52 | 4004.94 | 3810.53 | 3651.18 | 3704.58 | 3602.89 | 3154.38 | 3032.38 | 3055.10 | 2716.42 | 2656.07 | 2329.08 | 2390.81 | 2092.26 | 1974.64 | 929.89 | 956.44 | 934.53 | 959.22 | 467.01 | 272.84 | 197.53 | 168.59 | 168.33 | NA | 228.30 | 299.45 | 311.32 | 303.02 | |
| Liabilities And Stockholders Equity | 4239.98 | 4205.04 | 4009.63 | 3824.39 | 3829.88 | 3839.07 | 3402.40 | 3391.94 | 3546.36 | 3535.26 | 3330.42 | 3433.55 | 3643.30 | 3472.31 | 3509.43 | 3255.27 | 3407.06 | 3307.28 | 3374.37 | 2279.62 | 2395.13 | 2541.62 | 2716.41 | 2014.00 | 1574.80 | 1675.65 | 1789.39 | 1923.14 | NA | 1994.73 | 1358.28 | 1434.28 | 1133.93 | |
| Stockholders Equity | 67.09 | 32.35 | -3.07 | -219.27 | -220.64 | -165.87 | -408.13 | -259.24 | -158.22 | -67.64 | 176.04 | 401.17 | 588.20 | 755.89 | 853.36 | 926.19 | 1016.25 | 1215.02 | 1399.73 | 1349.73 | 1438.69 | 1607.09 | 1757.19 | 1546.99 | 1301.96 | 1478.12 | 1620.80 | 1754.81 | NA | 1766.43 | 1058.84 | 1122.97 | 830.90 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Assets Current | 3295.28 | 3355.42 | 3172.86 | 2988.61 | 2982.70 | 2985.45 | 2524.05 | 2541.02 | 2692.25 | 2690.85 | 2471.64 | 2589.68 | 2808.58 | 2675.36 | 2725.16 | 2470.08 | 2614.78 | 2554.70 | 2160.45 | 1584.77 | 1715.86 | 1897.27 | 2063.77 | 1392.01 | 1200.70 | 1342.12 | 1502.56 | 1685.30 | NA | 1764.74 | 993.37 | 960.71 | 597.19 | |
| Cash And Cash Equivalents At Carrying Value | 966.43 | 1099.92 | 968.49 | 681.88 | 812.69 | 1033.02 | 657.80 | 672.25 | 866.39 | 1073.23 | 575.56 | 534.08 | 819.98 | 1093.99 | 745.77 | 379.54 | 496.58 | 496.70 | 580.83 | 467.78 | 547.18 | 923.30 | 1136.29 | 724.96 | 420.15 | 316.61 | 361.46 | 396.15 | NA | 645.36 | 202.04 | 408.67 | 171.08 | |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents | 968.65 | 1102.50 | 971.19 | 684.72 | 814.88 | 1035.21 | 659.98 | 674.41 | 868.56 | 1075.39 | 577.74 | 536.26 | 822.15 | 1096.46 | 748.07 | NA | 499.05 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | 397.88 | NA | 646.83 | NA | NA | 172.55 | |
| Accounts Receivable Net Current | 405.31 | 353.85 | 309.48 | 321.38 | 327.79 | 325.44 | 220.63 | 219.43 | 237.96 | 184.51 | 142.27 | 156.53 | 198.57 | 141.06 | 146.59 | 110.63 | 102.41 | 79.12 | 69.11 | 75.57 | 43.01 | 48.11 | 30.74 | 33.80 | 18.76 | 3.36 | NA | NA | NA | 34.00 | NA | NA | NA | |
| Inventory Net | 78.51 | 75.99 | 83.98 | 93.99 | 89.15 | 95.77 | 100.45 | 131.88 | 128.96 | 115.49 | 88.98 | 78.52 | 86.36 | 97.90 | 84.36 | 73.94 | 75.20 | 66.94 | 77.42 | 68.30 | 56.35 | 54.56 | 40.59 | 32.00 | 24.07 | NA | NA | NA | NA | NA | NA | NA | NA | |
| Inventory Finished Goods | 26.43 | 23.13 | 27.86 | 24.82 | 25.12 | 27.66 | 28.50 | 29.53 | 25.61 | 21.48 | 13.19 | 10.43 | 7.00 | 12.67 | 16.45 | 13.75 | 12.69 | 7.26 | 13.22 | 4.23 | 2.65 | 0.58 | 0.45 | 0.14 | 0.10 | NA | NA | NA | NA | NA | NA | NA | NA | |
| Prepaid Expense And Other Assets Current | 116.96 | 145.35 | 154.75 | 201.96 | 126.38 | 157.96 | 145.45 | 119.03 | 132.92 | 125.52 | 129.78 | 115.06 | 88.08 | 108.53 | 94.14 | 75.98 | 62.77 | 74.77 | 88.35 | 98.70 | 80.34 | 73.54 | 65.62 | 81.67 | 73.71 | 90.84 | 51.93 | 66.67 | NA | 40.12 | 30.43 | 22.03 | 18.13 | |
| Equity Securities Fv Ni | 8.16 | 8.32 | 9.89 | 11.26 | 11.18 | 10.41 | 27.26 | 25.86 | 28.12 | 23.05 | 30.90 | 32.00 | 66.97 | 72.55 | 52.53 | 56.97 | 44.63 | 57.22 | 86.31 | 38.08 | 13.97 | NA | NA | NA | 1.21 | 15.00 | 12.04 | NA | NA | NA | NA | NA | NA | |
| Available For Sale Securities Debt Securities | 1789.01 | 1681.18 | 1688.88 | 1734.91 | 1649.67 | 1380.95 | 1380.38 | 1376.76 | 1411.13 | 1238.13 | 1593.73 | 1727.45 | 1603.62 | 1171.32 | 1101.78 | 1273.03 | 1353.18 | 1294.95 | 1268.42 | 972.84 | 1315.15 | 1471.90 | 1589.33 | 1049.81 | 662.80 | 905.22 | 1074.16 | 1172.36 | NA | 1059.18 | 797.79 | 689.17 | 641.15 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Property Plant And Equipment Gross | 773.15 | NA | NA | NA | 749.13 | NA | NA | NA | 696.94 | NA | NA | NA | 642.37 | NA | NA | NA | 569.38 | NA | NA | NA | 501.34 | NA | NA | NA | 400.14 | NA | NA | NA | NA | 249.25 | NA | NA | NA | |
| Accumulated Depreciation Depletion And Amortization Property Plant And Equipment | 270.36 | NA | NA | NA | 223.08 | NA | NA | NA | 173.45 | NA | NA | NA | 140.41 | NA | NA | NA | 104.35 | NA | NA | NA | 76.16 | NA | NA | NA | 79.48 | NA | NA | NA | NA | 67.35 | NA | NA | NA | |
| Property Plant And Equipment Net | 502.78 | 507.00 | 517.16 | 523.46 | 526.06 | 525.59 | 527.47 | 523.03 | 523.49 | 514.82 | 508.20 | 504.39 | 501.96 | 484.94 | 470.70 | 464.57 | 465.03 | 444.69 | 439.13 | 429.81 | 425.18 | 396.46 | 371.77 | 341.71 | 320.66 | 272.65 | 227.84 | 201.98 | NA | 181.90 | 161.90 | 147.53 | 129.96 | |
| Other Assets Noncurrent | 65.31 | 77.62 | 71.92 | 67.46 | 72.00 | 75.16 | 92.69 | 63.45 | 66.09 | 61.40 | 77.27 | 69.82 | 60.20 | 35.27 | 34.59 | 42.68 | 45.05 | 37.93 | 20.40 | 19.03 | 18.07 | 9.63 | 9.69 | 9.04 | 8.62 | 16.06 | 14.17 | 5.21 | NA | 4.17 | 1.47 | 1.47 | 1.47 | |
| Equity Securities Fv Ni | 8.16 | 8.32 | 9.89 | 11.26 | 11.18 | 10.41 | 27.26 | 25.86 | 28.12 | 23.05 | 30.90 | 32.00 | 66.97 | 72.55 | 52.53 | 56.97 | 44.63 | 57.22 | 86.31 | 38.08 | 13.97 | NA | NA | NA | 1.21 | 15.00 | 12.04 | NA | NA | NA | NA | NA | NA | |
| Available For Sale Debt Securities Amortized Cost Basis | 1787.46 | 1674.85 | 1691.63 | 1736.93 | 1648.13 | 1386.44 | 1387.75 | 1382.11 | 1420.60 | 1250.76 | 1604.31 | 1736.30 | 1605.24 | 1171.29 | 1101.68 | 1272.68 | 1352.83 | 1294.05 | 1266.04 | 968.66 | 1315.01 | 1471.55 | 1588.92 | 1049.87 | 663.22 | 905.82 | 1075.18 | 1174.42 | NA | 1060.82 | 798.74 | 690.34 | 642.18 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liabilities Current | 1186.27 | 1220.66 | 1055.25 | 941.71 | 967.79 | 949.78 | 788.64 | 673.39 | 767.91 | 772.79 | 657.68 | 605.96 | 695.71 | 610.66 | 554.65 | 494.82 | 585.27 | 480.24 | 384.30 | 338.79 | 352.59 | 352.86 | 328.60 | 149.16 | 179.49 | 121.50 | 113.66 | 115.38 | NA | 144.25 | 101.05 | 108.73 | 95.79 | |
| Accounts Payable Current | 88.42 | 70.81 | 73.98 | 78.15 | 55.52 | 73.84 | 59.75 | 62.24 | 98.09 | 40.57 | 52.42 | 54.92 | 73.43 | 40.05 | 53.08 | 45.38 | 51.97 | 27.87 | 26.12 | 40.48 | 49.88 | 39.39 | 71.22 | 22.67 | 59.71 | 21.77 | 11.99 | 13.21 | NA | 28.36 | 9.24 | 23.17 | 25.37 | |
| Other Accrued Liabilities Current | 123.16 | NA | NA | NA | 53.96 | NA | NA | NA | 59.54 | NA | NA | NA | 46.15 | NA | NA | NA | 49.59 | NA | NA | NA | 27.09 | NA | NA | NA | 23.63 | NA | NA | NA | NA | 10.86 | NA | NA | NA | |
| Accrued Liabilities Current | 887.47 | 946.17 | 808.64 | 698.87 | 713.01 | 713.09 | 598.53 | 508.60 | 545.46 | 510.58 | 421.24 | 355.94 | 395.17 | 388.58 | 341.19 | 280.53 | 355.91 | 295.26 | 211.19 | 183.22 | 197.20 | 177.95 | 138.80 | 106.87 | 112.72 | 93.56 | 89.87 | 63.82 | NA | 72.20 | 51.26 | 43.82 | 31.84 | |
| Contract With Customer Liability Current | 55.48 | 71.03 | 69.01 | 76.85 | 102.75 | 77.14 | 54.64 | 35.79 | 42.10 | 144.21 | 114.29 | 131.84 | 149.48 | 115.04 | 98.14 | 116.34 | 127.21 | 114.60 | 107.59 | 86.04 | 77.82 | 107.36 | 89.24 | 2.64 | 3.50 | 3.44 | 9.16 | NA | NA | 41.70 | NA | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Other Liabilities Noncurrent | 398.11 | 357.48 | 350.43 | 319.99 | 308.44 | 280.73 | 257.05 | 224.05 | 212.58 | 183.00 | 157.30 | 120.83 | 98.96 | 76.45 | 71.63 | 60.46 | 37.91 | 16.34 | 18.86 | 9.20 | 9.33 | 9.04 | 9.51 | 5.07 | 4.96 | 4.33 | 4.19 | 4.46 | NA | 4.35 | 2.84 | 2.81 | 3.18 | |
| Operating Lease Liability Noncurrent | 229.54 | 236.03 | 239.35 | 237.83 | 243.10 | 247.71 | 253.42 | 259.40 | 261.34 | 266.32 | 272.02 | 277.39 | 281.35 | 286.03 | 288.56 | 288.01 | 293.04 | 297.26 | 281.62 | 275.78 | 276.13 | 276.46 | 277.21 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stockholders Equity | 67.09 | 32.35 | -3.07 | -219.27 | -220.64 | -165.87 | -408.13 | -259.24 | -158.22 | -67.64 | 176.04 | 401.17 | 588.20 | 755.89 | 853.36 | 926.19 | 1016.25 | 1215.02 | 1399.73 | 1349.73 | 1438.69 | 1607.09 | 1757.19 | 1546.99 | 1301.96 | 1478.12 | 1620.80 | 1754.81 | NA | 1766.43 | 1058.84 | 1122.97 | 830.90 | |
| Common Stock Value | 1.29 | 1.29 | 1.28 | 1.26 | 1.26 | 1.25 | 1.25 | 1.24 | 1.24 | 1.23 | 1.21 | 1.21 | 1.20 | 1.20 | 1.19 | 1.17 | 1.16 | 1.16 | 1.16 | 1.13 | 1.12 | 1.11 | 1.11 | 1.06 | 1.01 | 1.01 | 1.00 | 1.00 | NA | 1.00 | 0.92 | 0.92 | 0.86 | |
| Additional Paid In Capital Common Stock | 7388.06 | 7259.88 | 7122.70 | 6881.98 | 6811.06 | 6736.94 | 6647.17 | 6522.09 | 6454.54 | 6336.77 | 6172.99 | 6116.56 | 6058.45 | 5968.66 | 5863.48 | 5747.39 | 5644.07 | 5592.88 | 5520.32 | 5289.97 | 5201.18 | 5091.25 | 5034.28 | 4601.66 | 4175.14 | 4140.03 | 4037.85 | 4009.34 | NA | 3947.55 | 3097.11 | 3038.53 | 2627.97 | |
| Retained Earnings Accumulated Deficit | -7287.75 | -7203.98 | -7092.41 | -7075.53 | -7009.59 | -6871.72 | -7019.47 | -6743.45 | -6569.35 | -6361.86 | -5955.94 | -5678.53 | -5438.19 | -5179.73 | -4975.22 | -4785.66 | -4585.37 | -4341.83 | -4088.54 | -3909.31 | -3727.09 | -3450.90 | -3242.37 | -3022.89 | -2840.97 | -2629.53 | -2384.25 | -2220.69 | NA | -2147.68 | -2005.46 | -1882.52 | -1764.10 | |
| Accumulated Other Comprehensive Income Loss Net Of Tax | -34.52 | -24.83 | -34.64 | -26.99 | -23.38 | -32.34 | -37.08 | -39.12 | -44.65 | -43.78 | -42.22 | -38.06 | -33.26 | -34.23 | -36.08 | -36.72 | -43.62 | -37.19 | -33.21 | -32.06 | -36.52 | -34.37 | -35.83 | -32.85 | -33.21 | -33.39 | -33.81 | -34.85 | NA | -34.43 | -33.74 | -33.96 | -33.83 | |
| Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value | NA | 46.61 | 90.10 | 46.16 | NA | 64.87 | 76.99 | 41.14 | NA | 129.13 | 34.45 | 30.05 | NA | 33.70 | 32.93 | 56.30 | NA | 40.23 | 33.71 | 34.58 | NA | 46.66 | 30.80 | 32.54 | NA | 88.41 | 22.00 | 19.46 | NA | NA | NA | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Operating Activities | -94.66 | 43.71 | 124.16 | -81.52 | -29.80 | 359.41 | -58.99 | -166.47 | -131.98 | -115.28 | -122.82 | -171.19 | -150.14 | -134.04 | -121.86 | -235.66 | -123.14 | -110.33 | -135.33 | -246.16 | -195.98 | -182.63 | 288.69 | -188.51 | -150.46 | -153.81 | -102.69 | -155.66 | NA | -103.04 | -98.36 | NA | NA | |
| Net Cash Provided By Used In Investing Activities | -52.91 | -30.25 | 33.94 | -67.62 | -240.66 | -10.76 | -8.71 | -76.22 | -139.91 | 313.89 | 142.79 | -147.42 | -413.40 | -88.27 | 157.02 | 71.35 | -97.89 | -10.09 | -441.23 | 113.69 | -220.85 | -10.08 | -289.40 | 102.65 | 248.96 | 96.17 | 62.62 | -134.81 | NA | -160.59 | -137.18 | NA | NA | |
| Net Cash Provided By Used In Financing Activities | 31.00 | 102.75 | 131.50 | 28.91 | 39.23 | 33.14 | 53.39 | 46.37 | 63.44 | 297.02 | 30.34 | 34.96 | 292.29 | 573.84 | 329.81 | 51.18 | 217.95 | 34.15 | 689.01 | 53.87 | 40.34 | -20.70 | 412.61 | 390.93 | 5.38 | 12.99 | 5.58 | 41.52 | NA | 706.95 | 28.91 | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Operating Activities | -94.66 | 43.71 | 124.16 | -81.52 | -29.80 | 359.41 | -58.99 | -166.47 | -131.98 | -115.28 | -122.82 | -171.19 | -150.14 | -134.04 | -121.86 | -235.66 | -123.14 | -110.33 | -135.33 | -246.16 | -195.98 | -182.63 | 288.69 | -188.51 | -150.46 | -153.81 | -102.69 | -155.66 | NA | -103.04 | -98.36 | NA | NA | |
| Net Income Loss | -83.76 | -111.57 | -16.89 | -65.94 | -137.87 | 147.75 | -276.02 | -174.10 | -207.49 | -405.92 | -277.40 | -240.34 | -258.46 | -204.51 | -189.56 | -200.29 | -243.54 | -253.29 | -179.23 | -182.22 | -276.19 | -208.53 | -219.48 | -181.91 | -211.44 | -245.28 | -163.56 | -141.21 | NA | -142.23 | -122.94 | -118.42 | -107.29 | |
| Increase Decrease In Accounts Receivable | 59.51 | 37.09 | -9.64 | -0.41 | -3.87 | 107.99 | 2.97 | -19.15 | 53.27 | 38.42 | -6.40 | -39.70 | 59.45 | -3.67 | 35.31 | 10.71 | 21.17 | 8.97 | -6.78 | 32.88 | -5.48 | 17.78 | -3.11 | 15.04 | 15.40 | 0.40 | -47.81 | 16.77 | NA | 19.36 | NA | NA | NA | |
| Increase Decrease In Inventories | -0.85 | -5.92 | -6.79 | -0.02 | -11.99 | -4.79 | -1.99 | 0.40 | 18.98 | 7.88 | 9.20 | -1.93 | 10.76 | 13.63 | 3.96 | -1.93 | 8.46 | 2.78 | 12.23 | 11.95 | 4.32 | 13.05 | 7.91 | 7.13 | 12.29 | NA | NA | NA | NA | NA | NA | NA | NA | |
| Share Based Compensation | 91.64 | 45.80 | 89.29 | 45.35 | 41.99 | 63.94 | 75.80 | 39.95 | 42.77 | 128.12 | 30.47 | 29.29 | 44.58 | 33.37 | 32.08 | 55.69 | 34.28 | 37.26 | 33.76 | 34.58 | 66.20 | 46.01 | 30.60 | 32.03 | 27.97 | 87.95 | 22.24 | 19.58 | NA | 27.12 | 25.95 | 24.03 | 15.72 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Investing Activities | -52.91 | -30.25 | 33.94 | -67.62 | -240.66 | -10.76 | -8.71 | -76.22 | -139.91 | 313.89 | 142.79 | -147.42 | -413.40 | -88.27 | 157.02 | 71.35 | -97.89 | -10.09 | -441.23 | 113.69 | -220.85 | -10.08 | -289.40 | 102.65 | 248.96 | 96.17 | 62.62 | -134.81 | NA | -160.59 | -137.18 | NA | NA | |
| Payments To Acquire Property Plant And Equipment | 9.09 | 4.19 | 8.02 | 12.97 | 15.31 | 17.09 | 15.92 | 13.89 | 21.64 | 16.51 | 16.05 | 17.86 | 21.89 | 26.06 | 11.25 | 17.18 | 21.67 | 12.42 | 16.66 | 19.62 | 38.80 | 36.06 | 21.24 | 44.05 | 37.51 | 45.41 | 22.71 | 21.26 | NA | 20.73 | 25.68 | 21.65 | 36.15 |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Financing Activities | 31.00 | 102.75 | 131.50 | 28.91 | 39.23 | 33.14 | 53.39 | 46.37 | 63.44 | 297.02 | 30.34 | 34.96 | 292.29 | 573.84 | 329.81 | 51.18 | 217.95 | 34.15 | 689.01 | 53.87 | 40.34 | -20.70 | 412.61 | 390.93 | 5.38 | 12.99 | 5.58 | 41.52 | NA | 706.95 | 28.91 | NA | NA |
| 2024-12-31 | 2024-09-30 | 2024-06-30 | 2024-03-31 | 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | 2018-12-31 | 2018-09-30 | 2018-06-30 | 2018-03-31 | 2018-01-01 | 2017-12-31 | 2017-09-30 | 2017-06-30 | 2017-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenues | 593.17 | 500.92 | 659.83 | 494.33 | 439.72 | 750.53 | 318.75 | 319.29 | 335.04 | 264.31 | 224.82 | 213.26 | 258.54 | 187.63 | 220.55 | 177.57 | 163.56 | 125.85 | 103.96 | 99.48 | 71.68 | 70.06 | 44.71 | 33.29 | 21.03 | 2.07 | 29.91 | 21.90 | 2.90 | 37.92 | 17.10 | 15.93 | 18.96 | |
| Revenue From Contract With Customer Excluding Assessed Tax | 593.17 | 500.92 | 659.83 | 494.33 | 439.72 | 750.53 | 318.75 | 319.29 | 335.04 | 264.31 | 224.82 | 213.26 | 258.54 | 187.63 | 220.55 | 177.57 | 163.56 | 125.85 | 103.96 | 99.48 | 71.68 | 70.06 | 44.71 | 33.29 | 21.03 | 2.07 | 29.91 | 21.90 | 2.90 | 37.92 | 17.10 | 15.93 | 18.96 | |
| Regeneron Pharmaceuticals Incorporation, C5 License Obligation, Global Strategic Collaboration | 19.44 | 8.40 | 8.80 | 1.70 | -21.10 | 0.70 | 3.10 | 2.20 | 34.60 | 1.40 | -4.80 | 1.30 | 14.20 | 1.20 | 15.70 | 13.50 | NA | NA | 0.00 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Regeneron Pharmaceuticals Incorporation, Research Services Obligation, Global Strategic Collaboration | 9.30 | 11.10 | 4.00 | 14.70 | 13.50 | 73.00 | -17.00 | 10.70 | 9.50 | 10.30 | 1.60 | 7.20 | 8.70 | 8.90 | 10.20 | 9.80 | 11.50 | 10.70 | 10.30 | 12.30 | 9.20 | 11.10 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Roche, Development Services Obligation, Roche Collaboration And License Agreement | 10.92 | 14.88 | 12.80 | 7.15 | 23.77 | 0.20 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Roche, License Obligation, Roche Collaboration And License Agreement | 0.00 | 0.00 | 0.00 | 65.00 | 0.00 | 310.00 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Novartis, Collaborative Arrangement | NA | 2.94 | 2.30 | 14.52 | NA | 18.38 | 8.63 | 14.93 | NA | 5.80 | 8.53 | 13.14 | NA | 4.16 | 8.91 | 8.11 | NA | 1.09 | 3.88 | 1.06 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Other Collaborations, Collaborative Arrangement | 4.27 | 0.21 | 1.10 | 2.59 | 2.09 | 17.51 | 0.05 | 1.54 | -0.24 | 1.51 | 0.48 | 0.40 | 0.50 | 0.58 | 0.10 | 0.52 | 0.14 | 1.75 | 0.32 | 0.46 | 0.06 | 0.46 | 0.31 | 0.21 | 0.03 | 0.21 | 0.06 | 0.51 | NA | 3.01 | 0.24 | NA | NA | |
| Regeneron Pharmaceuticals Incorporation, Global Strategic Collaboration | 28.74 | 19.50 | 12.80 | 17.10 | -6.40 | 75.70 | -12.20 | 15.40 | 54.78 | 17.10 | -1.50 | 10.80 | 25.40 | 12.60 | 37.30 | 25.80 | 20.80 | 13.10 | 13.20 | 16.50 | 8.50 | 14.70 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Regeneron Pharmaceuticals Incorporation, Collaborative Arrangement | 30.66 | 37.95 | 207.43 | 26.76 | 3.06 | 80.25 | -2.84 | 19.99 | 53.44 | 21.98 | 0.01 | 12.41 | 22.32 | 14.16 | 46.40 | 30.34 | 24.28 | 14.87 | 15.41 | 19.50 | 10.11 | 15.26 | 0.70 | 0.00 | 0.00 | 0.00 | NA | NA | NA | NA | NA | NA | NA | |
| Roche, Roche Collaboration And License Agreement | 10.92 | 14.88 | 12.80 | 72.15 | 23.77 | 310.20 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Roche, Collaborative Arrangement | NA | 16.29 | 16.51 | 74.68 | NA | 311.33 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Amvuttra | 286.51 | 258.59 | 230.11 | 195.24 | 175.25 | 148.68 | 132.14 | 101.77 | 68.57 | 25.23 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Collaborations | 106.95 | 57.39 | 227.34 | 118.55 | 76.41 | 427.47 | 5.84 | 36.46 | 70.64 | 29.30 | 9.03 | 25.95 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| GIVLAARI | 64.64 | 71.04 | 62.13 | 58.06 | 59.30 | 54.15 | 57.90 | 47.91 | 47.06 | 45.66 | 45.15 | 35.28 | 40.68 | 31.83 | 30.63 | 24.67 | 22.14 | 16.69 | 11.00 | 5.27 | NA | NA | 0.00 | 0.00 | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| ONPATTRO | 56.10 | 50.29 | 77.24 | 69.22 | 79.01 | 81.59 | 91.46 | 102.49 | 122.22 | 144.95 | 153.43 | 137.01 | 138.63 | 120.32 | 113.84 | 101.95 | 90.37 | 82.52 | 66.53 | 66.66 | 55.80 | 46.07 | 38.23 | 26.29 | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| OXLUMO | 43.57 | 40.22 | 40.61 | 42.65 | 32.73 | 28.74 | 24.21 | 24.16 | 23.83 | 16.43 | 14.94 | 14.59 | 19.20 | 14.89 | 16.34 | 9.14 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Product | 450.83 | 420.15 | 410.09 | 365.16 | 346.29 | 313.15 | 305.70 | 276.33 | 261.68 | 232.27 | 213.51 | 186.87 | 198.51 | 167.04 | 160.81 | 135.77 | 112.84 | 99.21 | 77.53 | 71.94 | 55.95 | 46.07 | 38.23 | 26.29 | 12.07 | 0.46 | NA | 0.00 | NA | NA | NA | NA | NA | |
| Royalty | 35.39 | 23.39 | 22.40 | 10.62 | 17.02 | 9.90 | 7.21 | 6.50 | 2.71 | 2.74 | 2.28 | 0.44 | 0.40 | 0.45 | 0.35 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Amvuttra, | 69.81 | 65.14 | 56.76 | 43.73 | 30.31 | 19.42 | 14.40 | 6.77 | 4.04 | 0.17 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Amvuttra,US | 183.25 | 168.66 | 148.46 | 130.24 | 122.18 | 113.51 | 96.47 | 79.01 | 57.46 | 25.06 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Amvuttra, Non U S Or Europe | 33.45 | 24.79 | 24.89 | 21.27 | 22.77 | 15.76 | 21.26 | 15.99 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| GIVLAARI, | 18.00 | 16.28 | 16.31 | 15.31 | 16.55 | 12.43 | 14.05 | 14.47 | 12.61 | 12.48 | 13.89 | 9.69 | 8.43 | 7.57 | 8.02 | 6.87 | 5.08 | 4.58 | 2.34 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| GIVLAARI,US | 45.05 | 40.37 | 41.23 | 38.73 | 39.46 | 37.01 | 35.20 | 30.29 | 31.15 | 31.17 | 29.66 | 23.68 | 30.25 | 22.37 | 22.37 | 17.76 | 16.75 | 12.11 | 8.66 | 5.27 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| GIVLAARI, Non U S Or Europe | 1.60 | 14.39 | 4.59 | 4.01 | 3.29 | 4.71 | 8.65 | 3.14 | 3.29 | 2.01 | 1.59 | 1.91 | 2.00 | 1.89 | 0.24 | 0.04 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| ONPATTRO, | 28.11 | 24.33 | 37.07 | 44.69 | 44.47 | 50.37 | 56.39 | 59.68 | 56.88 | 57.22 | 56.79 | 53.18 | 53.86 | 51.02 | 44.90 | 40.65 | 33.09 | 30.48 | 23.02 | 21.17 | 15.67 | 10.86 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| ONPATTRO,US | 19.93 | 16.21 | 22.11 | 16.54 | 20.49 | 21.87 | 25.56 | 29.82 | 46.16 | 67.20 | 71.08 | 62.31 | 60.10 | 51.25 | 52.39 | 49.47 | 43.08 | 39.03 | 32.27 | 37.20 | 35.76 | 33.59 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| ONPATTRO, Non U S Or Europe | 8.07 | 9.76 | 18.06 | 7.99 | 14.04 | 9.35 | 9.51 | 13.00 | 19.18 | 20.54 | 25.56 | 21.52 | 24.67 | 18.05 | 16.54 | 11.83 | 14.19 | 13.01 | 11.25 | 8.30 | 4.37 | 1.62 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| OXLUMO, | 18.85 | 19.98 | 20.50 | 21.43 | 19.41 | 15.09 | 12.22 | 13.31 | 12.82 | 9.35 | 7.59 | 8.16 | 11.72 | 9.66 | 9.83 | 7.74 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| OXLUMO,US | 18.76 | 14.93 | 15.74 | 13.33 | 10.60 | 9.71 | 8.79 | 9.06 | 8.78 | 6.38 | 7.12 | 5.41 | 5.72 | 5.24 | 6.51 | 1.41 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| OXLUMO, Non U S Or Europe | 5.97 | 5.31 | 4.36 | 7.89 | 2.72 | 3.94 | 3.20 | 1.79 | 2.23 | 0.70 | 0.22 | 1.02 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Collaborative Arrangement | 106.95 | 57.39 | 227.34 | 118.55 | 76.41 | 427.47 | 5.84 | 36.46 | 70.64 | 29.30 | 9.03 | 25.95 | 59.62 | 20.14 | 59.40 | 41.80 | 50.72 | 26.65 | 26.43 | 27.54 | 15.73 | 24.00 | 6.48 | 7.00 | 8.96 | 1.61 | 29.91 | 21.90 | NA | 37.92 | 17.10 | 15.93 | NA |
