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2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Common Stock Value 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.00

dei: Entity Common Stock Shares Outstanding NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA

Weighted Average Number Of Diluted Shares Outstanding 192.88 95.45 94.87 NA 91.18 76.67 75.89 NA 75.00 74.67 74.09 NA 72.25 66.60 61.89 NA NA NA NA NA

Weighted Average Number Of Shares Outstanding Basic 192.88 95.45 94.87 NA 91.18 76.67 75.89 NA 75.00 74.67 74.09 NA 72.25 66.60 61.89 NA NA NA NA NA

Earnings Per Share Basic -0.21 -0.45 -0.52 -0.57 -0.65 -0.74 -0.76 -0.75 -0.80 -0.80 -0.78 -0.88 -0.80 -1.00 -0.87 NA NA NA NA NA

Earnings Per Share Diluted -0.21 -0.45 -0.52 -0.57 -0.65 -0.74 -0.76 -0.75 -0.80 -0.80 -0.78 -0.88 -0.80 -1.00 -0.87 NA NA NA NA NA

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Operating Expenses 40.49 46.30 47.94 54.36 56.02 53.87 54.34 51.66 55.66 55.60 53.20 60.09 53.57 65.34 54.97 55.79 49.99 46.35 34.02 39.81

Research And Development Expense Excluding Acquired In Process Cost 31.20 36.31 37.80 41.51 44.51 42.58 42.32 40.93 43.19 44.32 41.83 38.91 41.85 38.68 41.41 42.60 40.15 35.68 24.98 25.87

General And Administrative Expense 9.29 9.98 10.13 12.83 11.50 11.28 12.00 10.71 12.46 11.26 11.35 15.88 11.45 11.65 10.75 11.59 9.84 9.67 8.03 13.94

Operating Income Loss -40.49 -46.30 -47.94 -54.36 -56.02 -53.87 -54.34 -51.66 -55.66 -55.60 -53.20 -60.09 -53.57 -65.34 -54.97 -55.79 -49.99 -46.35 -34.02 -39.81

Interest Expense 3.34 3.43 3.50 3.46 3.48 3.48 3.47 4.94 4.89 4.83 4.78 4.75 4.71 2.49 0.71 NA NA NA NA NA

Interest Paid Net 0.55 5.62 0.66 5.67 0.68 5.69 0.68 5.68 0.69 5.69 0.68 5.96 0.67 0.62 0.62 0.62 NA NA NA NA

Allocated Share Based Compensation Expense 6.16 8.20 8.13 11.45 10.12 10.00 10.98 7.66 7.59 8.05 8.71 12.68 8.92 8.90 8.24 6.86 5.73 5.14 3.09 10.80

Profit Loss -40.01 -42.50 -49.16 -55.76 -59.36 -56.47 -57.78 -56.28 -60.25 -59.83 -57.64 -64.60 -57.81 -66.87 -54.07 -54.70 -48.50 -44.50 -32.61 -38.79

Net Income Loss -40.01 -42.50 -49.16 -55.76 -59.36 -56.47 -57.78 -56.28 -60.25 -59.83 -57.64 -64.60 -57.81 -66.87 -54.07 -54.70 -48.50 -44.50 -32.61 -38.79

Comprehensive Income Net Of Tax -40.15 -42.54 -49.03 -55.75 -59.43 -56.64 -58.17 -56.38 -60.38 -59.72 -58.08 -64.35 -58.04 -65.80 -54.84 -54.77 -48.67 -44.08 -32.47 -39.09

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Assets 347.93 181.75 219.91 272.45 323.54 245.84 294.68 343.66 387.04 432.51 482.47 539.43 584.18 625.08 371.48 426.60 469.75 507.17 515.95 239.42

Liabilities 243.31 244.55 248.36 260.37 267.19 262.31 264.52 222.19 217.23 211.82 210.38 218.75 212.08 204.75 65.02 74.12 70.88 65.73 35.69 21.12

Liabilities And Stockholders Equity 347.93 181.75 219.91 272.45 323.54 245.84 294.68 343.66 387.04 432.51 482.47 539.43 584.18 625.08 371.48 426.60 469.75 507.17 515.95 239.42

Stockholders Equity 104.62 -62.80 -28.46 12.08 56.35 -16.46 30.16 121.46 169.81 220.69 272.08 320.68 372.10 420.32 306.46 352.49 398.87 441.44 480.26 -120.07

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Assets Current 341.49 173.38 210.41 261.88 312.03 232.68 280.77 331.78 373.99 416.99 465.85 522.32 566.21 608.40 355.44 409.32 452.37 489.59 497.79 231.95

Cash And Cash Equivalents At Carrying Value 82.61 37.00 65.24 111.97 153.48 94.32 138.91 183.40 213.47 342.45 439.66 486.06 461.96 486.06 111.35 135.09 130.71 148.50 170.85 105.22

Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents 82.61 37.00 65.24 111.97 153.48 94.32 138.97 183.47 213.54 343.02 440.22 486.62 461.96 486.06 111.35 135.09 130.71 148.50 170.85 105.42

Marketable Securities Current 246.28 125.12 136.61 143.71 150.91 127.84 132.72 141.81 152.55 63.47 13.64 26.57 93.42 114.30 234.81 266.74 315.76 315.50 310.37 123.44

Prepaid Expense And Other Assets Current 12.60 11.25 8.56 6.20 7.65 10.52 9.09 6.50 7.91 10.50 11.98 9.13 10.83 8.04 9.27 7.49 5.90 25.59 16.57 3.10

Available For Sale Securities Debt Securities 246.28 125.12 136.61 143.71 150.91 127.84 132.72 141.81 152.55 63.47 13.64 26.57 93.42 114.30 234.81 266.74 315.76 315.50 310.37 NA

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Property Plant And Equipment Gross 7.00 10.09 10.09 10.09 9.96 9.88 9.76 9.60 9.52 9.10 8.96 8.16 7.97 7.65 7.21 6.64 6.05 5.49 4.58 3.49

Accumulated Depreciation Depletion And Amortization Property Plant And Equipment 5.06 7.04 6.58 6.11 5.65 5.19 4.73 4.28 3.90 3.46 3.04 2.62 2.26 1.89 1.54 1.21 0.92 0.67 0.47 0.30

Property Plant And Equipment Net 1.94 3.05 3.52 3.98 4.30 4.69 5.03 5.32 5.62 5.63 5.92 5.53 5.72 5.76 5.67 5.42 5.13 4.81 4.11 3.19

Other Assets Noncurrent 0.65 0.77 0.74 0.68 0.63 1.25 1.02 1.08 1.11 1.07 1.01 1.03 0.86 0.63 0.63 1.56 1.39 1.37 2.13 4.27

Available For Sale Debt Securities Amortized Cost Basis 246.30 125.18 136.62 143.83 151.26 128.31 133.14 141.86 152.56 63.40 13.53 26.40 93.12 113.71 235.21 266.46 315.31 314.99 310.24 NA

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Liabilities Current 42.32 40.14 40.57 49.23 52.65 44.41 34.57 39.86 35.90 29.98 29.44 38.65 32.61 27.54 28.36 36.92 33.17 27.51 25.15 20.40

Accounts Payable Current 1.25 2.21 2.73 1.46 0.36 3.91 0.59 3.24 1.19 0.90 1.07 7.51 0.86 0.22 2.60 0.96 2.56 3.03 4.55 2.18

Other Accrued Liabilities Current 0.77 0.76 0.97 0.94 0.85 0.54 0.69 0.84 0.81 0.62 0.73 0.74 0.61 0.53 0.54 1.13 0.73 0.78 1.86 0.77

Accrued Liabilities Current 17.46 14.26 14.70 20.53 31.54 26.23 17.02 20.41 20.91 15.88 16.86 20.71 19.50 14.17 8.96 16.71 11.44 9.20 7.88 7.57

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Long Term Debt Noncurrent 3.63 6.44 9.22 11.99 14.83 17.64 29.17 29.08 28.99 28.91 28.82 28.74 28.66 28.64 28.55 28.46 NA NA NA NA

Operating Lease Liability Noncurrent 0.99 1.83 2.65 3.45 4.21 4.97 5.71 3.22 3.96 6.17 6.95 7.71 8.65 7.86 8.11 8.74 NA NA NA NA

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Stockholders Equity 104.62 -62.80 -28.46 12.08 56.35 -16.46 30.16 121.46 169.81 220.69 272.08 320.68 372.10 420.32 306.46 352.49 398.87 441.44 480.26 -120.07

Common Stock Value 0.02 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.01 0.00

Additional Paid In Capital Common Stock 1269.10 1061.56 1053.36 1044.86 1033.38 901.14 891.12 932.94 924.91 915.41 907.09 897.61 884.68 874.86 695.21 686.39 678.01 671.91 666.65 33.85

Retained Earnings Accumulated Deficit -1163.89 -1123.88 -1081.39 -1032.22 -976.46 -917.10 -860.63 -811.53 -755.25 -695.00 -635.17 -577.53 -512.93 -455.11 -388.24 -334.17 -279.47 -230.97 -186.47 -153.86

Accumulated Other Comprehensive Income Loss Net Of Tax -0.62 -0.48 -0.44 -0.57 -0.58 -0.51 -0.34 0.04 0.14 0.27 0.16 0.60 0.34 0.57 -0.51 0.26 0.33 0.50 0.08 -0.06

Stock Issued During Period Value New Issues 201.32 NA NA NA 119.93 NA NA NA NA NA NA NA NA 117.09 NA NA NA NA 291.34 NA

Adjustments To Additional Paid In Capital Sharebased Compensation Requisite Service Period Recognition Value 6.16 8.20 8.13 NA 10.12 10.00 10.98 NA 7.59 8.05 8.71 NA 8.92 8.90 8.24 NA 5.73 5.14 3.09 NA

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Net Cash Provided By Used In Operating Activities -34.49 -38.25 -52.99 -47.73 -37.00 -48.82 -53.48 -40.51 -42.03 -47.45 -58.90 -36.74 -44.93 -42.40 -52.30 -44.14 -36.11 -36.81 -27.77 -25.02

Net Cash Provided By Used In Investing Activities -118.26 12.94 8.72 8.46 -22.60 4.68 8.42 10.44 -89.76 -50.08 11.97 61.10 19.96 106.25 28.04 46.93 17.95 -13.88 -198.14 -8.68

Net Cash Provided By Used In Financing Activities 198.50 -2.90 -2.54 -2.87 119.22 0.02 0.72 0.37 1.91 0.27 0.77 0.25 0.89 310.83 0.57 1.52 0.37 28.35 291.34 -2.14

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Net Cash Provided By Used In Operating Activities -34.49 -38.25 -52.99 -47.73 -37.00 -48.82 -53.48 -40.51 -42.03 -47.45 -58.90 -36.74 -44.93 -42.40 -52.30 -44.14 -36.11 -36.81 -27.77 -25.02

Net Income Loss -40.01 -42.50 -49.16 -55.76 -59.36 -56.47 -57.78 -56.28 -60.25 -59.83 -57.64 -64.60 -57.81 -66.87 -54.07 -54.70 -48.50 -44.50 -32.61 -38.79

Profit Loss -40.01 -42.50 -49.16 -55.76 -59.36 -56.47 -57.78 -56.28 -60.25 -59.83 -57.64 -64.60 -57.81 -66.87 -54.07 -54.70 -48.50 -44.50 -32.61 -38.79

Depreciation Depletion And Amortization 0.40 0.50 0.47 0.46 0.50 0.50 0.45 0.45 0.50 0.40 0.42 0.36 0.36 0.35 0.33 0.29 0.25 0.20 0.17 0.13

Increase Decrease In Accounts Payable -0.99 -0.51 1.22 0.28 -3.30 3.71 -2.51 2.38 -0.18 -0.07 -6.57 6.97 0.74 -2.34 1.61 -1.73 -0.49 -1.31 2.13 -1.44

Share Based Compensation 6.16 8.20 8.13 11.45 10.12 10.00 10.98 7.66 7.59 8.05 8.71 12.68 8.92 8.90 8.24 6.86 5.73 5.14 3.09 10.80

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Net Cash Provided By Used In Investing Activities -118.26 12.94 8.72 8.46 -22.60 4.68 8.42 10.44 -89.76 -50.08 11.97 61.10 19.96 106.25 28.04 46.93 17.95 -13.88 -198.14 -8.68

Payments To Acquire Property Plant And Equipment NA NA NA 0.10 0.03 0.12 0.16 0.08 0.52 0.14 0.80 0.25 0.30 0.44 0.51 0.53 0.71 1.38 0.35 0.32

2023-09-30 2023-06-30 2023-03-31 2022-12-31 2022-09-30 2022-06-30 2022-03-31 2021-12-31 2021-09-30 2021-06-30 2021-03-31 2020-12-31 2020-09-30 2020-06-30 2020-03-31 2019-12-31 2019-09-30 2019-06-30 2019-03-31 2018-12-31

Net Cash Provided By Used In Financing Activities 198.50 -2.90 -2.54 -2.87 119.22 0.02 0.72 0.37 1.91 0.27 0.77 0.25 0.89 310.83 0.57 1.52 0.37 28.35 291.34 -2.14

Plots across concepts

Expenses

Interest Expense

Balance Sheet

Operating Lease Right Of Use Asset

Assets

Property Plant And Equipment Net

Current Assets

Prepaid Expense And Other Assets Current

NonCurrent Assets

Other Assets Noncurrent

PropertyPlantAndEquipmentNet

Property Plant And Equipment Net

Liabilities

Operating Lease Liability

Current Liabilities

Other Accrued Liabilities Current

Noncurrent Liabilities

Operating Lease Liability Noncurrent

Stockholders Equity

Retained Earnings Accumulated Deficit

CashFlow

Net Cash Provided By Used In Investing Activities

NetCashProvidedByUsedInOperatingActivities

Net Income Loss

NetCashProvidedByUsedInInvestingActivities

Net Cash Provided By Used In Investing Activities

NetCashProvidedByUsedInFinancingActivities

Repayments Of Long Term Debt

Shares

Common Stock Shares Issued

OperatingLeaseLiability

Operating Lease Liability Noncurrent

NonoperatingIncomeExpense

Nonoperating Income Expense

LesseeOperatingLeaseLiabilityPaymentsDue

Lessee Operating Lease Liability Payments Due Year Three

Line plots across dimensions of each concept

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