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| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Common Stock Value | 0.12 | 0.11 | 0.10 | 0.09 | 0.07 | 0.07 | 0.07 | 0.06 | 0.06 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | |
| Earnings Per Share Basic | -0.50 | -0.37 | -0.46 | -0.79 | -0.74 | -0.81 | -1.05 | -0.93 | -1.53 | -2.62 | -1.67 | -3.50 | -3.89 | -3.07 | 4.50 | -2.84 | -2.26 | -2.52 | -2.01 | 3.26 | |
| Earnings Per Share Diluted | -0.50 | -0.37 | -0.46 | -0.79 | -0.74 | -0.81 | -1.05 | -0.93 | -1.53 | -2.62 | -1.67 | -3.50 | -3.89 | -3.07 | 4.32 | -2.84 | -2.26 | -2.52 | -2.01 | 3.07 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue From Contract With Customer Excluding Assessed Tax | 32.25 | 33.97 | 25.79 | 24.33 | 18.82 | 18.98 | 18.84 | 18.84 | 15.40 | 14.41 | 40.66 | 7.98 | 9.64 | 3.83 | 212.24 | 1.84 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Revenues | 32.25 | 33.97 | 25.79 | 24.33 | 18.82 | 18.98 | 18.84 | 18.84 | 15.40 | 14.41 | 40.66 | 7.98 | 9.64 | 3.83 | 212.24 | 1.84 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Operating Expenses | 74.62 | 61.50 | 62.84 | 72.93 | 61.33 | 60.60 | 71.22 | 61.83 | 71.03 | 70.15 | 73.19 | 90.80 | 105.21 | 84.38 | 83.07 | 76.29 | 59.95 | 66.75 | 56.28 | 58.49 | |
| Research And Development Expense Excluding Acquired In Process Cost | 17.74 | 14.88 | 22.10 | 31.38 | 33.03 | 29.14 | 32.43 | 24.32 | 27.62 | 25.33 | 25.07 | 27.95 | 41.96 | 35.28 | 34.99 | 34.70 | 38.23 | 48.28 | 42.79 | 46.31 | |
| Selling General And Administrative Expense | 45.42 | 33.24 | 33.96 | 29.90 | 24.14 | 24.95 | 29.61 | 30.38 | 38.34 | 39.27 | 46.32 | 61.06 | 61.55 | 48.83 | 47.68 | 41.55 | 21.71 | 18.47 | 13.49 | 12.18 | |
| Operating Income Loss | -42.37 | -27.53 | -37.06 | -48.60 | -42.51 | -41.62 | -52.38 | -42.99 | -55.63 | -55.74 | -32.53 | -82.82 | -95.57 | -80.55 | 129.17 | -74.45 | -58.96 | -65.77 | -55.30 | 86.93 | |
| Interest Expense | 15.06 | 14.99 | 14.54 | 14.39 | 14.33 | 14.15 | 14.27 | 14.06 | 13.43 | 13.65 | 11.14 | 8.12 | 8.93 | 4.93 | 4.64 | 4.17 | 4.12 | 4.00 | NA | NA | |
| Net Income Loss | -56.34 | -41.25 | -49.94 | -61.72 | -55.49 | -55.12 | -66.32 | -56.73 | -65.12 | -69.39 | -43.67 | -90.94 | -104.48 | -85.44 | 124.61 | -78.25 | -61.95 | -68.38 | -54.22 | 87.38 | |
| Comprehensive Income Net Of Tax | -56.34 | -41.25 | -49.93 | -61.72 | -55.40 | -54.91 | -66.36 | -56.96 | -65.15 | -69.39 | -43.67 | -90.94 | -104.48 | -85.44 | 124.60 | -78.26 | -61.93 | -68.35 | -54.13 | 87.59 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Assets | 205.80 | 221.31 | 234.63 | 251.82 | 247.94 | 312.83 | 303.98 | 342.85 | 381.59 | 225.26 | 280.46 | 278.61 | 353.26 | 250.97 | 330.35 | 179.64 | 214.45 | 255.27 | 308.81 | 236.48 | |
| Liabilities | 660.79 | 631.31 | 606.60 | 581.48 | 571.72 | 606.93 | 595.68 | 591.89 | 578.53 | 587.96 | 584.77 | 548.00 | 449.39 | 242.01 | 244.86 | 229.89 | 194.50 | 186.76 | 179.48 | 61.47 | |
| Liabilities And Stockholders Equity | 205.80 | 221.31 | 234.63 | 251.82 | 247.94 | 312.83 | 303.98 | 342.85 | 381.59 | 225.26 | 280.46 | 278.61 | 353.26 | 250.97 | 330.35 | 179.64 | 214.45 | 255.27 | 308.81 | 236.48 | |
| Stockholders Equity | -454.99 | -410.00 | -371.98 | -329.66 | -323.78 | -294.10 | -291.70 | -249.04 | -196.94 | -362.70 | -304.31 | -269.39 | -96.13 | 8.96 | 85.49 | -50.25 | 19.95 | 68.51 | 129.33 | 175.01 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Assets Current | 201.06 | 218.23 | 232.12 | 250.60 | 246.68 | 261.79 | 252.48 | 290.82 | 328.97 | 170.67 | 275.17 | 272.57 | 345.90 | 242.80 | 321.37 | 172.63 | 211.71 | 253.46 | 307.12 | 235.22 | |
| Cash And Cash Equivalents At Carrying Value | 82.25 | 114.83 | 138.47 | 144.91 | 124.78 | 159.40 | 122.94 | 150.36 | 208.89 | 103.67 | 219.19 | 217.94 | 304.96 | 215.75 | 298.49 | 149.39 | 166.13 | 211.98 | 274.34 | 174.84 | |
| Cash Cash Equivalents Restricted Cash And Restricted Cash Equivalents | 82.25 | 114.83 | 138.47 | 144.91 | 124.78 | 209.40 | 172.94 | 200.36 | 258.89 | 153.67 | 219.19 | 217.94 | 304.96 | 215.75 | 298.49 | 150.31 | 167.06 | 212.91 | 275.27 | 176.03 | |
| Accounts Receivable Net Current | 48.49 | 42.62 | 40.80 | 36.41 | 33.73 | 31.49 | 27.84 | 25.12 | 22.93 | 21.71 | 21.85 | 17.25 | 12.39 | NA | NA | NA | NA | NA | NA | NA | |
| Inventory Net | 65.62 | 51.44 | 45.68 | 39.35 | 35.20 | 29.55 | 29.23 | 35.65 | 34.39 | 33.97 | 23.71 | 20.03 | 16.14 | 9.06 | 8.25 | 1.84 | NA | NA | NA | NA | |
| Prepaid Expense And Other Assets Current | 4.51 | 6.29 | 4.32 | 5.58 | 9.87 | 9.21 | 9.18 | 10.85 | 11.17 | 10.33 | 9.77 | 34.16 | 23.95 | 16.88 | 11.50 | 11.35 | 3.92 | 2.76 | 0.79 | 0.92 | |
| Available For Sale Securities Debt Securities | 68.85 | 88.78 | 112.51 | 131.39 | 152.56 | 179.19 | 179.81 | 209.29 | 239.57 | 130.77 | 201.73 | 206.80 | 281.78 | 206.15 | NA | NA | 62.61 | NA | NA | NA |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Property Plant And Equipment Gross | 2.01 | NA | NA | NA | 2.71 | NA | NA | NA | 2.71 | NA | NA | NA | 2.85 | NA | NA | NA | 2.18 | NA | NA | NA | |
| Accumulated Depreciation Depletion And Amortization Property Plant And Equipment | 2.01 | NA | NA | NA | 2.55 | NA | NA | NA | 2.05 | NA | NA | NA | 1.57 | NA | NA | NA | 1.03 | NA | NA | NA | |
| Available For Sale Debt Securities Amortized Cost Basis | 68.85 | 88.78 | 112.51 | 131.40 | 152.56 | 179.28 | 180.11 | 209.55 | 239.61 | 130.77 | 201.73 | 206.80 | 281.78 | 206.15 | NA | NA | 62.59 | NA | NA | NA |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Liabilities Current | 156.22 | 137.71 | 107.17 | 95.49 | 92.31 | 82.34 | 82.28 | 79.08 | 73.35 | 78.48 | 82.64 | 97.89 | 94.07 | 75.95 | 83.88 | 73.45 | 66.08 | 57.52 | 54.31 | 60.02 | |
| Accounts Payable Current | 31.72 | 26.21 | 24.56 | 17.07 | 23.04 | 18.58 | 12.83 | 26.83 | 17.56 | 20.75 | 29.35 | 30.34 | 51.98 | 17.58 | 29.69 | 15.11 | 28.86 | 23.73 | 28.40 | 33.27 | |
| Other Accrued Liabilities Current | 25.00 | 0.29 | 0.04 | 0.12 | 35.19 | 0.04 | 0.02 | 0.04 | 30.41 | 0.05 | 0.11 | 0.18 | 24.79 | 3.34 | 3.40 | 3.21 | 11.87 | 9.94 | 4.81 | 3.77 | |
| Other Liabilities Current | 0.99 | NA | NA | NA | 0.28 | NA | NA | NA | 0.17 | NA | NA | NA | 6.45 | NA | NA | NA | 0.17 | NA | NA | NA | |
| Contract With Customer Liability Current | 25.40 | 19.72 | 15.63 | 12.16 | 3.51 | 4.04 | 5.03 | 3.79 | 5.68 | 3.07 | 3.93 | 2.54 | 1.66 | 1.66 | 1.13 | 1.17 | 2.15 | NA | NA | NA |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Lease Liability Noncurrent | 3.02 | 2.05 | 1.70 | 0.78 | 0.67 | 0.05 | 0.14 | 0.26 | 0.52 | 1.31 | 1.92 | 2.52 | 3.45 | 4.11 | 3.97 | 3.72 | 1.11 | 0.82 | 0.76 | 0.79 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Stockholders Equity | -454.99 | -410.00 | -371.98 | -329.66 | -323.78 | -294.10 | -291.70 | -249.04 | -196.94 | -362.70 | -304.31 | -269.39 | -96.13 | 8.96 | 85.49 | -50.25 | 19.95 | 68.51 | 129.33 | 175.01 | |
| Common Stock Value | 0.12 | 0.11 | 0.10 | 0.09 | 0.07 | 0.07 | 0.07 | 0.06 | 0.06 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | 0.03 | |
| Additional Paid In Capital | 1149.17 | 1137.82 | 1134.61 | 1127.00 | 1071.18 | 1045.47 | 992.96 | 969.27 | 964.40 | 733.52 | 722.53 | 713.78 | 797.65 | 743.27 | 734.37 | 723.23 | 715.17 | 701.79 | 694.27 | 685.82 | |
| Retained Earnings Accumulated Deficit | -1549.28 | -1492.94 | -1451.69 | -1401.76 | -1340.04 | -1284.55 | -1229.43 | -1163.11 | -1106.38 | -1041.26 | -971.87 | -928.20 | -838.82 | -734.34 | -648.90 | -773.51 | -695.27 | -633.32 | -564.94 | -510.72 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Operating Activities | -37.06 | -19.32 | -24.75 | -54.36 | -42.47 | -42.83 | -50.53 | -38.99 | -57.71 | -69.17 | -47.87 | -89.07 | -68.55 | -86.67 | 139.39 | -69.35 | -49.99 | -58.03 | -54.01 | 91.69 | |
| Net Cash Provided By Used In Investing Activities | 0.00 | 0.00 | 17.50 | 25.00 | -11.79 | 33.00 | 5.00 | -18.10 | NA | NA | NA | NA | -12.68 | 2.33 | 5.11 | 26.59 | -2.87 | -5.31 | 26.72 | 45.70 | |
| Net Cash Provided By Used In Financing Activities | 4.47 | -4.31 | 0.81 | 49.49 | -30.36 | 46.29 | 18.11 | -1.44 | 213.41 | 3.65 | 49.11 | 2.04 | 170.44 | 1.60 | 3.67 | 26.01 | 7.01 | 0.98 | 126.54 | 1.67 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Operating Activities | -37.06 | -19.32 | -24.75 | -54.36 | -42.47 | -42.83 | -50.53 | -38.99 | -57.71 | -69.17 | -47.87 | -89.07 | -68.55 | -86.67 | 139.39 | -69.35 | -49.99 | -58.03 | -54.01 | 91.69 | |
| Net Income Loss | -56.34 | -41.25 | -49.94 | -61.72 | -55.49 | -55.12 | -66.32 | -56.73 | -65.12 | -69.39 | -43.67 | -90.94 | -104.48 | -85.44 | 124.61 | -78.25 | -61.95 | -68.38 | -54.22 | 87.38 | |
| Increase Decrease In Accounts Receivable | 5.87 | 1.82 | 4.38 | 2.69 | 2.24 | 3.65 | 2.73 | 2.18 | 1.22 | -0.14 | 4.52 | 4.94 | 6.60 | 2.87 | NA | NA | NA | NA | NA | NA | |
| Increase Decrease In Inventories | 14.19 | 5.76 | 6.32 | 4.15 | 5.66 | 0.31 | -6.42 | 1.26 | 0.42 | 10.26 | 3.68 | 3.89 | 7.08 | 0.81 | 6.41 | 1.84 | NA | NA | NA | NA | |
| Increase Decrease In Accounts Payable | 5.50 | 1.66 | 7.49 | -5.97 | 4.47 | 5.77 | -14.03 | 9.39 | NA | -8.65 | -0.60 | -21.58 | 34.43 | -12.25 | 14.57 | -13.65 | 5.10 | -4.45 | -5.16 | -11.55 | |
| Share Based Compensation | 2.92 | 2.98 | 3.16 | 2.90 | 3.71 | 3.54 | 3.53 | 4.44 | 4.47 | 5.50 | 8.58 | 5.75 | 6.67 | 7.26 | 7.39 | 7.05 | 6.36 | 6.33 | 6.56 | 6.64 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Investing Activities | 0.00 | 0.00 | 17.50 | 25.00 | -11.79 | 33.00 | 5.00 | -18.10 | NA | NA | NA | NA | -12.68 | 2.33 | 5.11 | 26.59 | -2.87 | -5.31 | 26.72 | 45.70 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Cash Provided By Used In Financing Activities | 4.47 | -4.31 | 0.81 | 49.49 | -30.36 | 46.29 | 18.11 | -1.44 | 213.41 | 3.65 | 49.11 | 2.04 | 170.44 | 1.60 | 3.67 | 26.01 | 7.01 | 0.98 | 126.54 | 1.67 |
| 2023-12-31 | 2023-09-30 | 2023-06-30 | 2023-03-31 | 2022-12-31 | 2022-09-30 | 2022-06-30 | 2022-03-31 | 2021-12-31 | 2021-09-30 | 2021-06-30 | 2021-03-31 | 2020-12-31 | 2020-09-30 | 2020-06-30 | 2020-03-31 | 2019-12-31 | 2019-09-30 | 2019-06-30 | 2019-03-31 | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenues | 32.25 | 33.97 | 25.79 | 24.33 | 18.82 | 18.98 | 18.84 | 18.84 | 15.40 | 14.41 | 40.66 | 7.98 | 9.64 | 3.83 | 212.24 | 1.84 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Daiichi Sankyo Co Ltd, Collaborative Arrangement | 0.10 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 28.10 | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Collaboration Revenue | 11.49 | 13.72 | 5.49 | 7.30 | 3.85 | 5.02 | 5.26 | 5.48 | 3.21 | 3.51 | 30.05 | 1.63 | 1.47 | 0.50 | 211.63 | 0.98 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Product | 20.76 | 20.25 | 20.29 | 17.03 | 14.97 | 13.96 | 13.58 | 13.35 | 12.19 | 10.89 | 10.61 | 6.35 | 8.17 | 3.33 | 0.61 | 0.86 | NA | NA | NA | NA | |
| Revenue From Contract With Customer Excluding Assessed Tax | 32.25 | 33.97 | 25.79 | 24.33 | 18.82 | 18.98 | 18.84 | 18.84 | 15.40 | 14.41 | 40.66 | 7.98 | 9.64 | 3.83 | 212.24 | 1.84 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Daiichi Sankyo Co Ltd, Collaborative Arrangement | 0.10 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 0.20 | 28.10 | NA | NA | NA | NA | NA | NA | NA | NA | NA | |
| Collaboration Revenue | 11.49 | 13.72 | 5.49 | 7.30 | 3.85 | 5.02 | 5.26 | 5.48 | 3.21 | 3.51 | 30.05 | 1.63 | 1.47 | 0.50 | 211.63 | 0.98 | 0.98 | 0.98 | 0.98 | 145.42 | |
| Product | 20.76 | 20.25 | 20.29 | 17.03 | 14.97 | 13.96 | 13.58 | 13.35 | 12.19 | 10.89 | 10.61 | 6.35 | 8.17 | 3.33 | 0.61 | 0.86 | NA | NA | NA | NA |
